[HTML][HTML] Discovery and prioritization of variants and genes for kidney function in> 1.2 million individuals

…, SB Patil, VA Million Veteran Program… - Nature …, 2021 - nature.com
… (CKDGen) Consortium identified 264 associated genetic loci … all the list of loci identified by
the primary meta-analysis were … we here introduced large genetic analyses on eGFRcys in >…

The CKDGen Consortium: ten years of insights into the genetic basis of kidney function

A Köttgen, C Pattaro - Kidney international, 2020 - kidney-international.org
… A catalog of genetic loci associated with kidney function from analyses of a million
individuals. … A catalog of genetic loci associated with kidney function from …

[HTML][HTML] Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies

M Gorski, H Rasheed, A Teumer, LF Thomas… - Kidney international, 2022 - Elsevier
… to identify genetic loci associated with annual eGFR decline and CKD progression (defined
as eGFR decline among individuals with CKD at baseline) and to prioritize genes that may …

[HTML][HTML] Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline

M Gorski, B Jung, Y Li, PR Matias-Garcia, M Wuttke… - Kidney international, 2021 - Elsevier
… Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline…
61,078 individuals and approximately 3 million genetic variants did not identify any locus for …

Discovery and prioritization of variants and genes for kidney function in> 1.2 million individuals

KJ Stanzick, Y Li, M Gorski, M Wuttke, C Pattaro… - bioRxiv, 2020 - biorxiv.org
analysis of GWAS to increase our knowledge of genetic loci associated with kidney function
using data from >1.2 million … a list of prioritized genes located at novel kidney function loci by …

Discovery and fine-mapping of kidney function loci in first genome-wide association study in Africans

S Fatumo, T Chikowore, R Kalyesubula… - … molecular genetics, 2021 - academic.oup.com
… ancestry individuals. We used the Uganda GPC to: (i) identify … statistically interact with
identified genetic loci. Given these … component analysis using merged data for the 343 individuals

[HTML][HTML] Genome-wide association studies of CKD and related traits

A Tin, A Köttgen - Clinical Journal of the American Society of …, 2020 - journals.lww.com
… these recent GWAS of CKD and kidney functionrelated traits, … an individual’s cumulative
genetic predisposition for a disease, … characterization of associated genetic loci and their value, …

Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease

H Liu, T Doke, D Guo, X Sheng, Z Ma, J Park, HMT Vy… - … genetics, 2022 - nature.com
… , we define the genetic association with kidney function in 1.5 million individuals and identify
878 (126 new) loci. We map the … The list shows genes with a priority score of 8. f, Number of …

[HTML][HTML] Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci

CE Breeze, A Batorsky, MK Lee, MD Szeto, X Xu… - Genome medicine, 2021 - Springer
… We analyzed a total of 211 individuals with matching kidney … SNP analysis, we conducted
kidney cis-meQTL analysis on a … b FORGE2 analysis for eGFR SNPs from GWAS catalog: the …

[HTML][HTML] Multivariate canonical correlation analysis identifies additional genetic variants for chronic kidney disease

AJ Osborne, A Bierzynska, E Colby, U Andag… - npj Systems Biology …, 2024 - nature.com
… over 697 million people and causes over one million deaths … two individual-level CKD
genotype datasets (NURTURE-CKD … any kidney function associations in the GWAS Catalog, thus …